Metabolism Review https://metabolismreview.org Energy expenditure, insulin resistance and metabolic adaptation, without the folklore. en Sat, 03 Oct 2026 00:00:00 GMT How human energy expenditure is measured https://metabolismreview.org/energy-expenditure/ https://metabolismreview.org/energy-expenditure/ Doubly labelled water, indirect calorimetry and predictive equations — what each method can and cannot tell you about metabolic rate. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer Does dieting damage your metabolism? https://metabolismreview.org/metabolic-adaptation/ https://metabolismreview.org/metabolic-adaptation/ Adaptive thermogenesis after weight loss — how large the effect actually is according to systematic review, and whether it is permanent. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer Insulin resistance, mechanistically https://metabolismreview.org/insulin-resistance/ https://metabolismreview.org/insulin-resistance/ What insulin resistance is, what drives it, and why the popular carbohydrate-centred account is incomplete. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer Do continuous glucose monitors tell healthy people anything? https://metabolismreview.org/glucose-monitors/ https://metabolismreview.org/glucose-monitors/ CGM in people without diabetes — what glucose variability means, what a spike indicates, and where the evidence runs out. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer Brown fat and cold exposure https://metabolismreview.org/brown-fat/ https://metabolismreview.org/brown-fat/ Brown adipose tissue in adults — how much there is, what activates it, and its actual contribution to energy balance. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer "Your metabolism slows down after 30" — is it true? https://metabolismreview.org/claim/metabolism-slows-after-30/ https://metabolismreview.org/claim/metabolism-slows-after-30/ Mostly false. A large multi-national analysis of doubly-labelled-water data found total energy expenditure, adjusted for body composition, is stable from roughl Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer "Eating late at night makes you gain weight" — is it true? https://metabolismreview.org/claim/eating-late-makes-you-fat/ https://metabolismreview.org/claim/eating-late-makes-you-fat/ Partly true. Controlled feeding studies find later eating is associated with greater hunger, altered energy expenditure and changes in adipose gene expression, Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer "Breakfast kick-starts your metabolism" — is it true? https://metabolismreview.org/claim/breakfast-boosts-metabolism/ https://metabolismreview.org/claim/breakfast-boosts-metabolism/ Mostly false. Randomised trials of breakfast assignment find little effect on weight, and no meaningful effect on total energy expenditure. Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer "Eating too little puts you in starvation mode so you stop losing" — is it true? https://metabolismreview.org/claim/starvation-mode/ https://metabolismreview.org/claim/starvation-mode/ Partly true. Adaptive thermogenesis is real: energy expenditure falls somewhat more than body-composition change predicts, and the Biggest Loser follow-up docum Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer "Green tea and similar supplements burn fat" — is it true? https://metabolismreview.org/claim/green-tea-fat-burning/ https://metabolismreview.org/claim/green-tea-fat-burning/ Mostly false. Meta-analyses of catechin and caffeine preparations find effects on weight that are statistically detectable and clinically trivial — a fraction o Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer "A kilogram of muscle burns hundreds of calories a day" — is it true? https://metabolismreview.org/claim/muscle-burns-huge-calories/ https://metabolismreview.org/claim/muscle-burns-huge-calories/ Mostly false. Resting skeletal muscle uses roughly 13 kcal per kilogram per day. Adipose tissue uses about 4.5. Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer "Continuous glucose monitors reveal which foods are bad for you" — is it true? https://metabolismreview.org/claim/cgm-for-non-diabetics/ https://metabolismreview.org/claim/cgm-for-non-diabetics/ Partly true. Postprandial glucose responses genuinely vary between people for the same food. Whether acting on those readings improves outcomes in people withou Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer About Metabolism Review https://metabolismreview.org/about/ https://metabolismreview.org/about/ Who publishes Metabolism Review, how pages are researched, and how the site makes money. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer Editorial policy https://metabolismreview.org/editorial-policy/ https://metabolismreview.org/editorial-policy/ How Metabolism Review selects evidence, scores products and handles conflicts of interest. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer Affiliate and partnership disclosure https://metabolismreview.org/disclosure/ https://metabolismreview.org/disclosure/ Every commercial relationship that could affect what you read on Metabolism Review. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer Privacy https://metabolismreview.org/privacy/ https://metabolismreview.org/privacy/ What Metabolism Review collects — which is close to nothing. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer Research digest, 28 September 2026 https://metabolismreview.org/research/2026-09-28/ https://metabolismreview.org/research/2026-09-28/ 42 newly indexed peer-reviewed papers relevant to Metabolism Review, from 28 September 2026. Mon, 28 Sep 2026 00:00:00 GMT Stéphane Sprauer Research digest, 21 September 2026 https://metabolismreview.org/research/2026-09-21/ https://metabolismreview.org/research/2026-09-21/ 4 newly indexed peer-reviewed papers relevant to Metabolism Review, from 21 September 2026. Mon, 21 Sep 2026 00:00:00 GMT Stéphane Sprauer Research digest, 14 September 2026 https://metabolismreview.org/research/2026-09-14/ https://metabolismreview.org/research/2026-09-14/ 7 newly indexed peer-reviewed papers relevant to Metabolism Review, from 14 September 2026. Mon, 14 Sep 2026 00:00:00 GMT Stéphane Sprauer Research digest, 7 September 2026 https://metabolismreview.org/research/2026-09-07/ https://metabolismreview.org/research/2026-09-07/ 28 newly indexed peer-reviewed papers relevant to Metabolism Review, from 7 September 2026. Mon, 07 Sep 2026 00:00:00 GMT Stéphane Sprauer Research digest, 8 August 2026 https://metabolismreview.org/research/2026-08-08/ https://metabolismreview.org/research/2026-08-08/ No newly indexed research matched this site's topics in the week of 8 August 2026. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer Adaptive thermogenesis: what the evidence base looks like https://metabolismreview.org/evidence/adaptive-thermogenesis/ https://metabolismreview.org/evidence/adaptive-thermogenesis/ 17 publications on adaptive thermogenesis — how many trials, how much synthesis, how recent, and what that means. Mon, 10 Aug 2026 00:00:00 GMT Stéphane Sprauer Insulin resistance: what the evidence base looks like https://metabolismreview.org/evidence/insulin-resistance/ https://metabolismreview.org/evidence/insulin-resistance/ 23 publications on insulin resistance — how many trials, how much synthesis, how recent, and what that means. Mon, 10 Aug 2026 00:00:00 GMT Stéphane Sprauer Metabolic syndrome: what the evidence base looks like https://metabolismreview.org/evidence/metabolic-syndrome/ https://metabolismreview.org/evidence/metabolic-syndrome/ 19 publications on metabolic syndrome — how many trials, how much synthesis, how recent, and what that means. Mon, 10 Aug 2026 00:00:00 GMT Stéphane Sprauer Mitochondria: what the evidence base looks like https://metabolismreview.org/evidence/mitochondria/ https://metabolismreview.org/evidence/mitochondria/ 20 publications on mitochondria — how many trials, how much synthesis, how recent, and what that means. Mon, 10 Aug 2026 00:00:00 GMT Stéphane Sprauer Continuous glucose monitoring: what the evidence base looks like https://metabolismreview.org/evidence/cgm/ https://metabolismreview.org/evidence/cgm/ 24 publications on continuous glucose monitoring — how many trials, how much synthesis, how recent, and what that means. Mon, 10 Aug 2026 00:00:00 GMT Stéphane Sprauer Brown fat: what the evidence base looks like https://metabolismreview.org/evidence/brown-fat/ https://metabolismreview.org/evidence/brown-fat/ 19 publications on brown fat — how many trials, how much synthesis, how recent, and what that means. Mon, 10 Aug 2026 00:00:00 GMT Stéphane Sprauer Total energy expenditure: what the evidence base looks like https://metabolismreview.org/evidence/total-energy-expenditure/ https://metabolismreview.org/evidence/total-energy-expenditure/ 25 publications on total energy expenditure — how many trials, how much synthesis, how recent, and what that means. Mon, 10 Aug 2026 00:00:00 GMT Stéphane Sprauer Nutrient timing: what the evidence base looks like https://metabolismreview.org/evidence/nutrient-timing/ https://metabolismreview.org/evidence/nutrient-timing/ 16 publications on nutrient timing — how many trials, how much synthesis, how recent, and what that means. Mon, 10 Aug 2026 00:00:00 GMT Stéphane Sprauer Metabolic rate: what the evidence base looks like https://metabolismreview.org/evidence/metabolic-rate/ https://metabolismreview.org/evidence/metabolic-rate/ 15 publications on metabolic rate — how many trials, how much synthesis, how recent, and what that means. Mon, 10 Aug 2026 00:00:00 GMT Stéphane Sprauer Does cutting carbs raise your metabolic rate? https://metabolismreview.org/carbs-and-metabolic-rate/ https://metabolismreview.org/carbs-and-metabolic-rate/ Does cutting carbs raise your metabolic rate? What the controlled feeding trials and meta-analyses of the carbohydrate-insulin model actually found. Sat, 05 Sep 2026 00:00:00 GMT Stéphane Sprauer Does a low-carb diet burn more calories? https://metabolismreview.org/metabolic-advantage-low-carb/ https://metabolismreview.org/metabolic-advantage-low-carb/ The metabolic advantage claim, tested: what the reanalysis of 29 controlled feeding trials and the energy-expenditure studies say about low-carb diets. Thu, 03 Sep 2026 00:00:00 GMT Stéphane Sprauer